Chapter 6. Discussion

6.4 Conclusions

Triple negative breast cancer is still a highly unmet medical need and therefore target selection and preclinical testing are needed to provide rational drug

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combinations for clinical testing. Based on our in vitro evaluation of a range of inhibitors:



dasatinib and rapamycin are active and therefore warrant further investigation in triple negative breast cancer.



protein levels of EPHA2, CAV1 and CAV2 appear to be useful biomarkers of dasatinib response.



the combination of dasatinib and cisplatin exhibited synergy in inhibiting growth of triple negative cell lines.

Future clinical trials combining dasatinib with cisplatin and testing the validity of EPHA2, CAV1 and CAV2 as predictive biomarkers may thus be warranted in patients with advanced triple negative breast cancer.

65

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