• Algunas plantas como hinojo (Foeniculum
vulgare) y cajeput (Melaleuca leucadendron)
ejercen una inhibición reversible sobre los sistemas del CYP450, particularmente sobre CYP3A4 y CYP2D6, responsables del metabolismo de más de la mitad de los medicamentos farmacéuticos más frecuentemente utilizados.156 Por este motivo,
el uso concomitante de una mezcla de AEes por vía oral, puede aumentar la vida media de fármacos hasta en un 30%, aumentando el riesgo de efectos adversos en pacientes polimedicados.157 Las administraciones
inhalada y transdérmica son alternativas que reducen este riesgo.
• Puede interactuar con ciclosporina y otros medicamentos inmunosupresores disminuyendo su efectividad (debido al efecto inmunoestimulante de algunos aceites).
• Puede interactuar con fluorouracil y aumentar su penetración transdérmica.
• Puede reducir la actividad de la MAO.
• Puede aumentar la sensibilidad a la insulina y acentuar el efecto de medicamentos
hipoglicemiantes.
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