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Impact of Natural IgM Concentration on Gene Therapy with Adenovirus Type 5 Vectors

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Figure

FIG 1 Inverse correlation between natural IgM concentration and liver transduction. Wild-type C57BL/6 mice were compared to knockout mice that have abnormallylow or high levels of natural IgM (enzyme-linked immunosorbent assay (ELISA)
FIG 2 Influence of mouse strain on IgM concentration and liver transduction. C57BL/6, BALB/c, or hybrid mice were pre-bled to determine serum IgM11
FIG 3 Kupffer cells mediate the negative effect of natural antibodies on livertransduction

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