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Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling

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Figure

Fig. 1. Sulf1 inhibits the ability of Wnt8a to activate canonical Wnt signalling. (A–M)chordin Xenopus laevis embryos were microinjected with mRNA encoding Wnt8a(5 pg) and/or Sulf1 (1 ng) into a single ventral blastomere at the four-cell stage
Fig. 2. Sulf1 inhibits the ability of Wnt8a to activate canonical Wnt signalling. (A) A graph showing the response of the Topflash reporter in whole embryosto tRNA controls for specificity
Fig. 3. Sulf1 does not inhibit the ability of Wnt3a to induce axis duplication. (A–F) Xenopus laevis embryos were microinjected with mRNA encoding Wnt3a(5 pg) and/or Sulf1 (1 ng) into a single ventral blastomere at the four-cell stage
Fig. 4. Sulf1 enhances the ability of Wnt11b to activate both canonical and non-canonical Wnt signalling
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