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Inhibition of p53 by Adenovirus Type 12 E1B-55K Deregulates Cell Cycle Control and Sensitizes Tumor Cells to Genotoxic Agents

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Figure

FIG. 1. Repression of p53 target genes by Ad12 E1B-55K protein.Colon carcinoma cell line HCT116 was stably transduced with lentivi-
FIG. 4. Ad12 E1B-55K protein sensitizes HCT116 cells to genotoxic agents. HCT116 parental cell line and the isogenic line HCT116p53�(D) or doxorubicin (E)
FIG. 5. Effects of E1B-55K expression on cell proliferation. Theparental HCT116 cell line and the indicated derivatives were seeded in
FIG. 6. Ad12 E1B-55K protein sensitizes diverse tumor cells to genotoxic agents. Non-small-cell lung cancer cell lines H1299 and A549, hepatocellularcarcinoma cell line HepG2, and glioblastoma cell line A172 were stably transduced with empty vector or that
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