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Suppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles In Vitro by Cyclophilin Inhibitors

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FIG 2 CPIs interfere with HCV RNA association with the NS5A complex. (A)Input HCV RNA levels from JFH-FLAG-infected cells exposed to varioustreatments for 8 h
FIG 3 NS5A associates with both positive and negative strands of HCV RNA, in a CsA-dependent manner
FIG 4 Suppression of CyPA expression inhibits the production of infectious particles in vitro
FIG 5 The CPI ALV inhibits the production of infectious particles in addition to blocking RNA replication
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