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Role for Conserved Residues of Sindbis Virus Nonstructural Protein 2 Methyltransferase-Like Domain in Regulation of Minus-Strand Synthesis and Development of Cytopathic Infection

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Figure

FIG. 1. (A) Schematic for the functional organization of nsP2 in the genus Alphaviruspreviously mapped to nsP2 helicase, protease, and the MTase-like domain are indicated
TABLE 1. Plaque phenotypes at permissive and nonpermissivetemperatures of growth
FIG. 2. Analysis of growth and viability for nsP2 MTase-like do-main mutants. BHK-15 cells were infected with wild-type (SINV) or
FIG. 3. Analysis of protein synthesis and processing. (A) In vitro transcription and translation of nsP2 lethal (R615A, R699A, and K752A) andsmall-plaque mutants (K733A and R751A) using the rabbit reticulocyte lysate
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