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The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism

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Figure

Figure 1 Effect of eplerenone and PF-03882845 on urinary Na+/K+ in rats. Eplerenone (A) and PF-03882845 (B) elicited a dose-dependentincrease in urinary Na+/K+ ratio in Sprague-Dawley rats following administration of single doses
Figure 2 Effects of eplerenone on urinary log10 Na+/K+ in humans. Eplerenone elicited a dose-dependent increase in urinary Na+/K+ inhumans
Figure 4 Effect of chronic administration of eplerenone and PF-03882845 on plasma aldosteronerepresented as mean + SEM

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