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QLT0267, a small molecule inhibitor targeting integrin linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P AKT levels, altered F actin architecture and improved treatment outc

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Figure 1Breast cancer cells exhibit dose-dependent decrease in (a) cell viability and (b) P-AKT in response to increasing concentrations of the ILK small mol-Breast cancer cells exhibit dose-dependent decrease in (a) cell viability and (b) P-AKT in response to increasing concentrations of the ILK small mol-ecule inhibitor, QLT0267(a)
Table 1
Figure 2Breast cancer cells treated with 267 and docetaxel combined at a fixed ratio and added at various concentrations exhibit synergistic effects based on a measured cell viability endpointBreast cancer cells treated with 267 and docetaxel combined at a
Figure 4Dose response curves were generated for changes in P-AKT in LCC6 and LCC6Dose response curves were generated for changes in P-AKT in LCC6 and LCC6combination of QLT0267 and docetaxelHer2 Her2 cells after treatment with QLT0267, docetaxel, or a fixe
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