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Porcine Reproductive and Respiratory Syndrome Virus nsp1α Inhibits NF-κB Activation by Targeting the Linear Ubiquitin Chain Assembly Complex

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Figure

FIG 1 PRRSV infection suppresses LUBAC-mediated NF-0.1, or 0.2) or UV-inactivated PRRSV
FIG 2 Ectopic expression of nsp1�plasmid (0.1� efficiently blocked LUBAC-induced NF-�B activation
FIG 3 The CTE domain of nsp1cells were cotransfected with plasmid encoding the WT nsp1At 28 h after transfection, Western blot was used for detection of protein expression
FIG 4 nsp1� blocks NF-�B signaling upstream from IKK� by limiting M1-Ub accumulation on NEMO
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