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The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication

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Figure

FIG 1 MCPyV sT has characteristics of an Fe/S cluster protein. (A) BL21(DE3)pLysS bacteria were transformed with a plasmid encoding MBP-MCPyV sT
FIG 2 EPR spectra of purified wild-type MCPyV sT at 12 K and 1 mW (A) andat 40 K and 5 mW (B)
FIG 3 Sequence alignment of various polyomavirus sTs. (A) Amino acid sequences of selected polyomavirus sTs were obtained from NCBI and aligned usingMacVector 13
FIG 4 EPR spectra of purified MCPyV sT proteins. (A) EPR spectra of purified CA and CF-knockout MCPyV sT mutants at 12 K and 1 mW (a) and at 40 K andrespectively
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