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Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING

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Figure

FIG 1 Expression of STING reconstitutes sensing of cytoplasmic DNA in Tzm-bl cells. (A) Tzm-bl cells were transduced with CON- or STING-expressingare expressed as fold increases relative to results for mock-transfected cells
FIG 2 STING expression in Tzm-bl cells elevates ISG56 mRNA induction by HIV-1 but does not affect infection rates
FIG 3 Vpr reduces sensing of HIV-1 infection in Tzm-bl STING cells. (A to C) Tzm-bl CON or Tzm-bl STING cells were infected with 1.9indicated viruses and analyzed for infection efficiency (A) and induction of ISG56 (B) or IFN-independent experiments
FIG 4 Vpr reduces the sensitivity of HIV-1 for innate immune recognition in Tzm-bl STING cells
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