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A View of the E2-CD81 Interface at the Binding Site of a Neutralizing Antibody against Hepatitis C Virus

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Figure

FIG 1 mAb41 recognizes the consensus sequence WLXXL. (A) Results ofphage display screening with mAb41
FIG 3 mAb41 pages the E2-CD81 interaction. CD81-Fc was captured onprotein G magnetic beads and then incubated with E2-FLAG, with or withoutmAb41, Fab41, or Fab41 complexed with either epitope II or the epitope IImimic peptide
FIG 5 Epitope II peptide interferes with E2-CD81 interaction. E2-16Fc wasimmobilized on a protein A-coated luminescence plate and then incubatedwith CD81-Luc in the presence of different amounts of epitope II peptide,epitope II mimic peptide, or a non-E2 p
FIG 7 Molecular docking of epitope II peptide to CD81-LEL. (A) Cartoon representation of one of three predominant conformations of epitope II peptiderepresentation
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