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Tyrosine dephosphorylation of ASC modulates the activation of the NLRP3 and AIM2 inflammasomes

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Figure

FIGURE 2 | Inhibition of tyrosine dephosphorylation hinders ASC aggregation.≤and analyzed by immunoblot
FIGURE 3 | PAO inhibits the AIM2 inflammasome. LPS-primed THP-1 macrophages and BMDMs were transfected with poly(dA:dT) (1ANOVA with the Dunnett test
FIGURE 5 |p ≤ 0.01, ***p ≤ (C)Site-directed mutagenesis of Y36, Y60, Y137, and Y146 to phenylalanine was carried out and the NLRP3 inflammasome was reconstituted in HEK293T cells bytransfection of NLRP3, pro-casp-1, pro-IL-1 Residues Y60 and Y137 are requir

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