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The glucose transporter GLUT1 is required for ErbB2 induced mammary tumorigenesis

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Figure

Fig. 1 Loss of GLUT1 prevents HER2/ERBB2/Neu-induced mammary tumor development. a Kaplan-Meier curve of tumor-free survival in MMTV-NICmice with wild-type GLUT1 (Glut1+/+), one floxed GLUT1 allele (Glut1F/+) or two floxed GLUT1 alleles (Glut1F/F)
Fig. 2 Cre and GLUT1 expression in tumors from NIC mice with and without GLUT1. Representative images of a tumor from a NIC-GLUT1+/+mouse showing Cre staining (a), GLUT1 staining (b), and hematoxylin and eosin (H&E) staining (c)
Fig. 3 Reduced proliferation in mammary epithelium of mice lacking GLUT1.tumors and in mammary epithelium from wild-type ( a Quantification of percent Ki67-positive epithelial cells in tumor tissueand in non-tumor-bearing mammary glands
Fig. 4 GLUT1 expression decreases with increasing tumor size.( a GLUT1 protein levels are inversely correlated with tumor size
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