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Cleavage of the extracellular domain of junctional adhesion molecule A is associated with resistance to anti HER2 therapies in breast cancer settings

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Academic year: 2020

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Figure

Fig. 1 (See legend on next page.)
Fig. 2 BT-474 trastuzumab-resistant cells and SK-BR-3 lapatinib-resistant cells express increased levels of epidermal growth factorreceptor (EGFR) at both mRNA and protein level compared withtheir corresponding sensitive cells and JAM-A knockdown reducesEG
Fig. 3 JAM-A cleavage is augmented in BT-474 trastuzumab-of JAM-A mRNA expression in BT-474-Sens and BT-474-Tr cells.Representative Western blot images and densitometric analysis ofbasal JAM-A protein expression in BT-474-Sens and BT-474-Tr cells(relative
Fig. 4 Cleaved JAM-A levels are increased in the serum of patients with HER2-positive breast cancer resistant to HER2-targeted therapy
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