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CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection.

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Academic year: 2019

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FIG. 1. LCMV-specific serum IgG in CD40L�LCMV. Anti-LCMV IgG antibody was measured by ELISA as described previously (2)
FIG. 2. LCMV-specific IgG subtype profiles of CD40L�mice. (a) LCMV-specific ELISA was used to quantitate the amount of each IgGsubclass in serum at the indicated days postinfection
TABLE 2. Mice lacking CD40L eliminate an acute LCMVinfection and generate a primary effector CTL responsea
FIG. 4. CD40L is not required for CD8�At day 8 postinfection, spleen cells from CD40Lanalyzed by flow cytometry using antibodies specific to CD4, CD8, and CD44.CD44 represents an activation marker for T cells

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