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Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry.

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Figure

TABLE 1. Percentages of sequence homology between human andrhesus CCR5 and CXCR4
FIG. 1. Sequence alignment of human and rhesus CCR5 and CXCR4. Nucleotide sequences of CCR5 and CXCR4 cDNAs were derived from animals Rh-541 andRh-1550 by RT-PCR
FIG. 2. Rh-CCR5 mediates cell fusion with SIV or HIV-1 Env, but Rh-CXCR4 mediates fusion only with HIV-1
FIG. 3. Entry of luciferase reporter viruses into cells expressing human or rhesus coreceptors
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