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The bone metastasis niche in breast cancer– potential overlap with the haematopoietic stem cell niche in vivo

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Fig. 1. In vivoFemale BALB/c nude mice were injected i.c. MDA-MB-231-GFP cells transfectedwith luciferase, tumour growth was detected in the hind limbs using animaging system (IVIS)
Fig. 2. Homing of the bone-seeking MDA-MB-231-GFP-IV cell-line. (A) Experimental outline of theintravenously (i.v.) with PBS on day 0 followed by 1 × 10 in vivo study
Fig. 3. Location of MDA-MB-231-GFP-IV cells in the bone microenvironment. (A) Schematic illustration of the distances measured from the edge of the tumour cellsto the nearest bone surface and (B) to the closest other cancer cell
Fig. 4. Comparison between diferent routes of tumour cell injection. (A) Experimental outline of the in vivo study
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