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Hepatitis C Virus Core Protein Blocks Interferon Signaling by Interaction with the STAT1 SH2 Domain

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Figure

FIG. 2. HCV core expression does not downregulate STAT1 geneexpression. (A) Reverse transcription-PCR
FIG. 3. STAT1 binds to full-length and C-terminally truncatedHCV core in Huh7 cells treated with MG132 in an immunoprecipita-
FIG. 4. N-terminal HCV core is essential for interaction with STAT1, as shown by the immunoprecipitation of HCV core and Western blottingof anti-STAT1
FIG. 5. N-terminal HCV core (aa 1 to 23) inhibits IFN signaling and reduces P-STAT1. (A) Full-length HCV core and N-terminal HCV core(aa 1 to 23) expression suppresses IFN signaling in Huh7 cells
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