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U20 Is Responsible for Human Herpesvirus 6B Inhibition of Tumor Necrosis Factor Receptor-Dependent Signaling and Apoptosis

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Figure

FIG 1 HHV-6B infection inhibits TNF-�-induced apoptosis. (A) Confocal microscopy of HCT116 cells infected with HHV-6B for 48 h and stained with 7C7,an HHV-6A/B-specific antibody
FIG 2 HHV-6B infection inhibits proinflammatory and apoptotic TNFR1 signaling pathways
FIG 3 HHV-6B-encoded protein U20 inhibits TNF-�-induced apoptosis. (A) HCT116 cells were transfected with plasmid alone (mock) or a plasmid carryingU20 and left untreated or treated with TNF-� (25 ng/ml) and CHX (10 �M) for 4 h, followed by Western blot an
FIG 4 U20 is a 75-kDa membrane-associated protein. (A) PCR with primers spanning the2, 4, 8, 12, 24, or 48 h
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