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Promoting therapeutic angiogenesis of focal cerebral ischemia using thrombospondin 4 (TSP4) gene modified bone marrow stromal cells (BMSCs) in a rat model

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Figure

Fig. 1 Construction of the PLV-Easy-GFP-TSP4 plasmid and expression of the TSP4 target protein
Fig. 2 Effect of TSP4-BMSCs on HUVEC angiogenesis. a–c VEGF, TGFβ and TSP4 level in the supernatant of HUVECs incubated with BMSCs was detected by ELISA
Fig. 3 HUVECs incubation with BMSCs induced angiogenic factor expression and activated the TGFβ/Smad2/3 signalling pathway
Fig. 4 Establishment of a permanent middle cerebral artery occlusion (MCAO) model and expression of vWF and Ang-1 in ischemic brain penumbra of rats
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