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Selective Phosphonylation of 5′-Adenosine Monophosphate (5′-AMP) via Pyrophosphite [PPi(III)]

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Figure

Fig. 1 Condensed phosphorus oxyacids used as biological or envisaged as prebiotic energy currency moelcules
Fig. 2 Phosphonylation of 5′-AMP via Na2-PPi(III) showing P-transfer to 2′, 3′ & 5′ sites
Fig. 3 % PPi(III-V)-5T′-AMP formation in parallel reactions of PPi(III) (1.5 M) & 5′-AMP (0.1 M), H2O, pH 7, = 20 °C control and in the presence of G1 (1.0 M), G2 (1.0 M), MgCl2 (0.1 M) & MgCl2-G2 (0.1 M; 1.0 Mrespectively)
Fig. 4 % PPi(III-V)-5EtNHT′-AMP formation in parallel reactions of PPi(III) (1.5 M) & 5′-AMP (0.1 M), H2O, pH 7, = 20 °C control and in the presence of G1 (1.0 M), G2 (1.0 M), MgCl2 (0.1 M); MgCl2-G2; MgCl2 & NaOAc;3Cl and MgCl2 & EtNH3Cl (0.1 M; 1.0 M res
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