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Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance

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Figure

TABLE 1 Summary of glycoforms and their abundances found at the glycan epitopes of PGT135 by MALDI MS
FIG 3 Glycans present at the Asn392 and Asn386 glycosylation sites. gp120 was digested with chymotrypsin (Promega) before RP-HPLC and MALDI analysis.abundances (corresponded to the protonated masses
FIG 4 Influences of gp120 glycans on bnAb recognition. (A) Neutralization sensitivity of PGT135, PGT128, and b12 against BaL wild-type pseudovirus and(black) binding to wild-type (continuous line) and kifunensine-treated (dashed line) gp120

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