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Causal inference for long-term survival in randomised trials with treatment switching: Should re-censoring be applied when estimating counterfactual survival times?

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Figure 1. Trametinib compared to chemotherapy for metastatic melanoma: overall survival in primary efficacy population
Figure 2. One simulated dataset from Scenario 13 with no switching: (a) Overall survival Kaplan–Meier; (b) smoothed hazard rate.
Table 1. Scenarios 9 and 13 – performance measures for estimation of control arm RMST.
Figure 3. Percentage bias across all scenarios. ITT: intention to treat; TSE: two-stage estimation; TSEnr: two-stage estimationwithout re-censoring; RPSFTM: rank preserving structural failure time model; RPSFTMnr: rank preserving structural failure timemodel without re-censoring; CTE: common treatment effect.
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