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MiR 92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta catenin signaling pathway

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Figure

Figure 1 Expression and clinical significance of miR-92b in gliomas. (A) A heat map diagram generated by unsupervised clustering analysiswith 40 significantly deregulated miRNAs in eight human glioma tissues
Figure 2 The effects of miR-92b on proliferation and apoptosis in U251 and U87 cells. (A) Realtime PCR analysis of miR-92b expression inhuman astrocyte cell line (HA) and glioma cell lines (including U251, U87, SHG44 and A172)
Figure 3 DKK3protein was assayed as a control. Scanning densitometry of the blots was used to quantify the Western blotting data
Figure 4 The alternation of the Wnt/beta-catenin signal pathway.(100 nM), the control oligonucleotide (100 nM) or the miR-92b inhibitor (100 nM).the transfection.densitometry analysis of the blots was used to quantify the data.levels were assessed 48 h aft

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