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HIV 1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic intervention

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Figure

Figure 1 The role of Vpr in HIV-1 infection and host permissivenessphosphorylation of Chk1, which increases viral production
Figure 2 Summary of HIV-1 pathology involving Vpr. Vpr is likely important for both immune dysfunction as seen in AIDS and associateddiseases including HIV-D and HIVAN.
Figure 3 Proposed timeline for HIV-1 Vpr mediated pathology and resistance to therapy

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