Immature Monocyte-Derived Dendritic Cells Are Productively Infected with Herpes Simplex Virus Type 1

Following Flt3L immunization or DC depletion, the mice were ocularly in- fected with HSV-1 strain McKrae, and TGs from surviving mice were isolated individually on day 30 after

The binding of herpes simplex virus type 1 ICP4, TATA-binding protein (TBP), and RNA polymerase II (polII) to the promoter regions of representative immediate-early (IE) (ICP0),

Flow cytometric analysis using anti-CD14 (monocyte marker) and anti-CD83 (mature DC marker) revealed that expression of CD14 decreased in MCM plus heparin-treated DC, and

Notably, promoter-reporter constructs containing immediate-early (ICP0 and ICP4), early (ICP8 and UL9), and late (UL10 and UL30) viral promoters were induced only two- to fourfold

The regions of the herpes simplex virus type 1 immediate early protein Vmw 175 required for site specific DNA binding closely correspond to those involved in transcriptional

Herpes simplex virus type 1 (HSV-1) and some of its immediate-early genes stimulate expression of the human immunodeficiency virus (HIV) long terminal repeat (LTR) sequences and

major start site was detected either in the presence or absence of the immediate-early (alpha) genes encoding ICP4 or ICPO, which have been shown to stimulate ICP8 gene expression

As with our proteomic data, cell surface marker expression suggested that immature mDCs expressed lower levels of the usual DC maturation markers compared with both moDCs and