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Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery.

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Figure

FIG. 1. Flow cytometric analysis of �cytes. Purified human peripheral blood monocytes were cultured in the absence(control) or presence of 10 ng of GM-CSF per ml or 50 U of M-CSF per ml for48 h
FIG. 4. Adenovirus-mediated gene delivery into unstimulated and growthfactor-stimulated human monocytes
TABLE 1. Inhibition of adenovirus-mediated gene delivery intohuman monocytes by anti-�v integrin MAbs and RGD peptidesa
FIG. 6. Flow cytometric analysis of �phocytes. Unstimulated T cells and T cells stimulated with PHA, PMA, or acombination of these activating agents for 48 h were analyzed for expression ofintegrinsv integrin expression on human T lym- �v�3 (anti-�v�3 MAb LM609) and �v�5 (anti-�v�5 MAb P3G2) byflow cytometry.

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