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Exploration of interaction scoring criteria in the CANDO platform

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Figure

Fig. 1 CANDO platform workflow. a Binding sites are predicted for each of the 46,784 proteins in the CANDO protein structure library using the bioinformatic tool COFACTOR [20–23], resulting in a BSscore
Fig. 2 Comparison of indication accuracy distributions. A histogram of the non-zero accuracy values for the v1 (blue) and Best OBscore (yellow) pipelines at four cutoffs is plotted
Fig. 3 Accuracies and coverages of five CANDO pipelines at various cutoffs using different compound-protein interaction scoring metrics

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