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Replication of Subgenomic Hepatitis C Virus Replicons in Mouse Fibroblasts Is Facilitated by Deletion of Interferon Regulatory Factor 3 and Expression of Liver-Specific MicroRNA 122

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TABLE 1. Colony-forming efficiencies induced byHCV SGR-Bsd-JFH1 RNA
FIG. 2. Detection of NS5A protein in HCV replicon colony formation assays. Colonies obtained by blasticidin drug selection of HCVSGR-Bsd-JFH1 RNA in Huh-7 cells and WT and IRF-3-deficient (KO) MEFs were fixed and immunostained for NS5A with anti-NS5A or IgG
FIG. 3. HCV RNA does not induce an antiviral state against VSVin IRF-3-deficient (KO) MEFs
FIG. 5. HCV replicon RNA replicates efficiently in IRF-3-deficientMEFs stably expressing miR-122, introduced into cells by lentivirus transduc-

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