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Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope.

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FIG.1.constructedglycoproteinproviralmacrophage-tropicamino Amino acid sequence differences in the parental and V3 recombinant viruses
FIG. 3.virionsvisualizedAIDSlabeledlysedviralgp120bandsp55, Virion-associated gpl20 envelope glycoproteins
TABLE 2. Spontaneous loss of gpl20 from virions
FIG. 5.proteinsmixtureproteinsMethods. Spontaneous release of gpl20 from virions. Metobolically labeled virion suspensions were generated as described in Materials and Aliquots (100 ,ul) of the different suspensions were incubated at 37°C for 0 and 48 h, a
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