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SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways.

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Figure

Figure 1. Proteomic identification of integrin receptors as cargoes for SNX17. (A) The table lists transmembrane proteins that were at least threefold less abundant in SNX17-depleted HeLa cells compared with control
Figure 2. Flow cytometric analysis of surface integrins in SNX17-depleted HeLa cells. The histograms show levels of indicated integrins in control (red) and SNX17-depleted cells (blue) including an isotype control (gray)
Figure 3. SNX17 depletion decreases Itg51 recycling and leads to enhanced degradation of integrins caused by aberrant trafficking to lysosomes
Figure 4. SNX17 binds to the membrane-distal NPXY motifs in  integrins. (A) Confocal image of internalized antibody (TS2/16) against active Itg1, endogenous EEA1, and GFP-tagged SNX17 in human RPE1 cells after 30 min of internalization
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