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APOBEC3A, APOBEC3B, and APOBEC3H Haplotype 2 Restrict Human T-Lymphotropic Virus Type 1

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Figure

FIG 1 APOBEC3 restriction of HTLV-1 and HIV-1. (A) The indicated A3 expression plasmids were cotransfected with HTLV-1 helper (GagPol and nonstruc-indicated A3 plasmids in HEK-293T cells
FIG 2 Packaging of APOBEC3 into HTLV-1 virions. (A) The indicated A3 expression plasmids were cotransfected with an irrelevant plasmid (HTLV-1 helper plasmid (by immunoblotting and probed for A3 expression (HA), and tubulin served as a loading control.�) o
FIG 3 Comparison between human and macaque A3A restriction of HTLV-1. (A) Protein sequence alignment of human A3A andto determine whether differences between GFP and each A3 protein or between A3A mutants reach significance (using GraphPad Prism 5 software)
FIG 4 Deaminase activity requirements for restriction of HTLV-1 and HIV-1.
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