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The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Binds to HIF-1α and Causes Its Degradation via the Proteasome Pathway

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Figure

FIG 1 ORF34 suppresses the transcriptional activity of VEGF and EPO lucif-erase reporters mediated by HIF-1�
FIG 2 In vivo and in vitro interaction of ORF34 with HIF-1�. (A) Schematic diagram showing coding potentials of ORF34 and HIF-1� protein along withdifferent regulatory domains of HIF-1�
FIG 3 Identification of ORF34 regions that interact with HIF-1matic diagram showing the different deletion mutants of ORF34 (D1, D2, andD3) used in the IP assay
FIG 4 Identification of HIF-1� domains that interact with ORF34. (A) Sche-matic diagram showing the different deletion mutants of GST-HIF-1� (D1,D2, D3, and D4) used in the IP assay
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