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Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size

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Figure

FIG 1 Longitudinal measures of integrated HIV DNA in noncontrollers (NCs; n � 6 [A, D, and E]), elite controllers (ECs; n � 8 [B, D, and E]), and antiretroviraltherapy (ART)-treated patients (n � 4 [C, D, and E])
FIG 2 (A) Correlation between CD4/CD8 cell ratio and integrated HIV DNA in PBMCs ((IQR, 0.68 to 1.2) to 0.29 (IQR, 0.14 to 0.6)
FIG 3 Integrated HIV DNA in PBMCs (A and B) and CD4 T cells (C and D) from patients with acute and chronic infection at baseline and 12 months afterlog values, with the two groups compared using the Mann-Whitney U test
FIG 4 Correlation between pre-ART integrated HIV DNA and HIV load (r � 0.86; P � 0.0002) (A) and CD4/CD8 T-cell ratio (r � �0.52; P � 0.05) (B) inchronically (n � 6) and acutely infected (n � 7) patients.

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