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Effect of Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells on Mice Infected with Prions

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Figure

FIG. 1. Distribution of hMSCs to the neuropathological lesions of prion disease. At 120 dpi, hMSCs (1 �staining of the hypothalami of mice infected with strain Obihiro or Chandler are shown at 150 dpi
FIG. 2. Migration of hMSCs in response to prion-specific lesions. hMSCs (1 �infected with strain Chandler at 73, 100, or 120 dpi and into those of mock-infected mice at 120 dpi
FIG. 3. Migration of hMSCs into the brain after intravenous transplantation. hMSCs (1 �corpus callosum (CC), cortex (Cx), cerebellum (Cb), and medulla oblongata (MO) 3 weeks posttransplantation is shown
FIG. 4. Prolongation of survival of prion-infected mice by trans-plantation of hMSCs. For intracerebral (i.c.) transplantation, hMSCs
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