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TRIM Protein-Mediated Regulation of Inflammatory and Innate Immune Signaling and Its Association with Antiretroviral Activity

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FIG 1 TRIM proteins induce NF-�B and AP-1. (A and B) HEK293 cells were transfected with 5 or 25 ng of plasmids expressing the indicated TRIM proteins (seeTable S1 in the supplemental material) or bona fide inducer controls, with Renilla luciferase and NF-�B
FIG 3 TRIM62 is a novel protein involved in TLR4 signaling. (A) Schematic depicting the possible scenarios for activation of TAK1-dependent NF-protein in HEK293 cells stably expressing NTshRNA or shRNA targeting TRIM62
FIG 4 TRIM62 functions in the TRIF branch of the TLR4 signaling pathway. (A) Schematic of an LPS-triggered TLR4 signaling pathway that uses plasmamembrane-localized TIRAP/MyD88 as an adaptor to induce the early phase of TRAF6- and TAK1-dependent NF-LPS-TLR
FIG 5 TRIM62 is required for TRIF signaling in primary macrophages. (A) Quantitative real-time PCR analysis of TRIM62 mRNA levels normalized to GAPDH in
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