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Divergent Evolution of Norovirus GII/4 by Genome Recombination from May 2006 to February 2009 in Japan

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Figure

FIG. 1. Phylogenetic classification of the NoV GII/4 subtypes in Japan during 2006 and 2009
FIG. 3. Phylogenetic evidence for NoV genome mosaicism. (A) Maximum-likelihood trees of the nucleotide sequences of the complete ORF1(about 5.1 kb), ORF2 (about 1.6 kb), and ORF3 (about 0.8 kb)
FIG. 4. Isolation of NoV mosaic genome segments. Three genome segments (5.2, 1.0, and 2.8 kb) were amplified from the 2007a, 2007b, 2008a,and 2008b stool specimens, cloned into plasmid vectors, and sequenced
FIG. 5. Amino acid signatures of the NoV GII/4 subtypes. The deduced amino acid sequences of ORF1, ORF2, and ORF3 of a given GII/4subtype were aligned with the GII/4 sequences identified before the outbreak season of the subtype
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