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Time dependent cytotoxic drugs selectively cooperate with IL 18 for cancer chemo immunotherapy

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Figure

Figure 1 Topotecan and paclitaxel upregulate MHC-I and Fas on ID8 cells and exert their cytotoxic effects in a phase-specific mannersigmoidal and for the same time of exposure (6 hours) they plateau at a level that depends on the cell cycle specificity
Figure 2 Tumor cells surviving topotecan or paclitaxel are sensitized to effector T cellsdescribed) were incubated with the Fas agonistic antibody and recombinant protein G or with isotype matched antibody and recombinantprotein G for 24 hours, harvested,
Figure 3 IL-18 induces activation of T effector cells, restrictsascites accumulation and prolongs survival of ID8-Vegf tumorbearing mice
Figure 4 IL-18 improves only the antitumor effect of time-dependent drugsbenefit offered by paclitaxel and topotecan alone and restricts ascites accumulation (left)
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