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Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-κB Activation by Targeting p65 for Degradation

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Figure

FIG 1 Identification of MC132 as an inhibitor of TNF-triplicate samples from a representative experiment (instead of TNF-induce MC132 expression, and then, 24 h later, stimulated with 50 ng/ml TNF-�-stimulated NF-�B activation
FIG 2 Inhibition of IL-1 and TLR activation of NF-samples from a representative experiment (ples for panel A were probed for expression of Flag-tagged viral proteins
FIG 4 MC132 inhibits NF-�B activation by IKKs, a common convergence pointin the network of signal transduction pathways activated during viral infection.(A) Schematic showing multiple signal transduction pathways to NF-�B expectedto be activated during a p
FIG 5 MC132 expression causes a depletion of p65 protein expression. (A) Effect of inducible MC132 expression on TNF-�immunoblotted with the indicated antibodies
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