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C-Reactive Protein (CRP) Is Essential for Efficient Systemic Transduction of Recombinant Adeno-Associated Virus Vector 1 (rAAV-1) and rAAV-6 in Mice

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Academic year: 2019

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Figure

FIG 1 rAAV-6 is more efficient in the control C57BL/6 mice than in CRP-deficient mice. Mice received intravenous injections of increasing doses ofrAAV-6 (1 � 10E10, 5 � 10E10, and 2.5 � 10E11 vg of rAAV-6 coding forMuSEAP)
FIG 4 rAAV-1 and rAAV-6, but not rAAV-8 or rAAV-9, are more efficient in the control C57BL/6 mice than in CRP KO mice
FIG 5 mCRP restores transduction efficiency of rAAV-6 in CRP-deficientmice. (A) C57BL/6 (BL6) and C57BL/6 CRP KO (BL6 KO) mice were injectedintravenously with rAAV-6 CMV-Luc vector (dose of 5 � 10E10 vg) preincu-bated with either CRP-depleted or unfractionat
FIG 6 Blood vector clearance following intravenous injection is more rapid in CRP-deficient mice

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