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The Nef-Mediated AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Increased Fas/FasL Expression on T Cells and T-Cell Death but Is Not Prevented in Fas-, FasL-, Tumor Necrosis Factor Receptor 1-, or Interleukin-1β-

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Figure

FIG. 1. CD4�Thymocytes of Tg or control mice were analyzed by FACS analysis after staining with anti-CD4 and anti-CD8 MAbs and 7AAD
FIG. 2. Quantitation of apoptotic/dead CD4�anti-CD3 MAb. After incubation for 3 days, the cells were harvested;stained with anti-CD4, anti-CD8, and anti-TCRStudent’swith annexin V/PI; and analyzed by FACS analysis to obtain apoptosis/death profiles followin
FIG. 3. Expression of Fas and FasL on CD4 5) (white bar) and Tg (Student’s(histograms represent data pooled from six experiments with 11 non-Tg (white bar) and 14 Tg (black bar) (6- to 8-week-old) mice
TABLE 1. Gross and microscopic evaluation of CD4C/HIV Tgmice bred on ICE�/� or ICE�/� deficient background
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