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Infectious Bursal Disease Virus Activates c-Src To Promote α4β1 Integrin-Dependent Viral Entry by Modulating the Downstream Akt-RhoA GTPase-Actin Rearrangement Cascade

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Figure

FIG 1 IBDV infection elicits host c-Src tyrosine phosphorylation and activation in a cell line and(A) Time course of c-Src Y416 phosphorylation upon IBDV infection
FIG 2 Inhibition of c-Src activation by treatment with AZD0530 or overexpression of a c-Src dominantIBDV for either 1 h, 4 h, 12 h, or 24 h
FIG 3 IBDV-induced c-Src phosphorylation and activation are dependent on host cell surface integrin�integrin8), and shRNA-HSP90 (c, lane 10) effectively suppressed the expression of Flag-tagged ITGITGfrom three independent experiments.cells with stable exp
FIG 4 c-Src and the downstream molecule PI3K/Akt in the integrin signaling pathway are required forIBDV internalization
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