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Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age based dosing

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Table 1 Performance of optimized PQ regimen options by region and assessed TDRs
Fig. 1 Comparison of dosing accuracy for modelled dose ranges in Africa. Population under (red), over (blue) and correctly (white) dosed by age forAfrica using three dose ranges (0.1–0.4, 0.125–0.375 and 0.15–0.35 mg/kg)
Fig. 2 Predicted intake dose for selected body weight centiles by age for Africa, Asia and Latin America using a dose range of 0.15–0.35 mg/kg.Proportion of the population in the three regions predicted to receive doses between 0 and 15-0.35 mg/kg (tab = 3.75 mg) by age for PQ, blacktriangle indicates regimen cut-offs on the horizontal axis as follows: Africa = 6 months (mo)-3, 4–10, 11–15 and 16+ years; Asia =6mo-3, 4–11, 12–16 and 17+ years; Latin America = 6mo-2, 3–8, 9–13 and 14+ years

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