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Non-genomic regulation of intermediate conductance potassium channels by aldosterone in human colonic crypt cells

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Figure

Figure 1Photomicrograph of intact colonic crypts isolated by Cachelation and visualised using Hoffman modulated optics (2+×400).Note that the crypts were isolated devoid of non-epithelial cellsoriginating from the lamina propria
Figure 2Nonin pipette), showing rapid onset ofinhibition of Knmol/l aldosterone, with furtherinhibition after increasing thealdosterone concentration to 10nmol/l
Figure 3Non-genomic inhibition of intermediate conductancebasolateral K+ channels by aldosterone (ALDO)
Figure 5pH sensitivity of intermediate conductance basolateral Kchannels. Summary of data from eight excised inside out basolateralmembrane patches, showing the pattern of channel activity when thepH of the bath solution was varied between 6.8 and 7.6 (holdingvoltage+ −40 mV, referenced to pipette interior; 145 mmol/l K+ inbath and pipette).

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