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Chronic Subclinical Prion Disease Induced by Low-Dose Inoculum

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TABLE 1. ME7- or RML-induced clinical signs in tga20 micefollowing intracerebral inoculation
FIG. 1. Regression analysis of ME7 and RML incubation times. The incubation times for different preparations of RML and ME7 in tga20 micewere plotted as a best-fit curve as described by Prusiner et al
TABLE 4. Prion infectivity in the central nervous systems ofmice with subclinical ME7- or RML-induced diseasea
FIG. 2. Histology and immunocytochemistry. Sections of brain tissue were subjected to conventional staining with hematoxylin and eosin (rows1 and 3) and examined histologically to confirm prion pathology by the presence of microvacuolation
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