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Mutational Evidence for an Internal Fusion Peptide in Flavivirus Envelope Protein E

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Figure

FIG. 1. (A) Ribbon diagram of the ectodomain portion of the TBE virus E protein dimer (36) viewed from the top (perpendicular to the virionsurface), with the individual subunits colored red and blue
FIG. 2. Electron micrographs of wild-type and mutant RSPs stainedwith uranyl acetate.
FIG. 4. Antibody binding profiles before and after low-pH treatment. The binding activities of 18 E-protein-specific MAbs with low-pH-treatedand untreated RSP-wt (upper panel) and RSP-107D (middle panel) were compared by four-layer ELISA
FIG. 7. Liposome coflotation assay. RSPs were incubated with li-posomes at the indicated pHs and analyzed by sucrose step gradient

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