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Effects of Type I Interferons on the Adjuvant Properties of Plasmid Granulocyte-Macrophage Colony-Stimulating Factor In Vivo

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Figure

FIG. 1. PlasmidGM-CSF507 days postinoculation, muscles were isolated and homogenized andGM-CSF expression was measured by ELISA
FIG. 3. Plasmid DNA and plasmid GM-CSF recruited monocytes and APCs at the site of inoculation
FIG. 5. Administration of plasmid GM-CSF increased levels of IFN-�secretion were measured in plasmid GM-CSF-injected muscles (muscles/group) were inoculated with 50isolated and homogenized and IFN- in the muscle at the site of inoculation
FIG. 6. Administration of anti-IFN-�istered 50given 250ally at the same time. Luc expression was monitored by IVIS over theensuing 21 days, and expression is expressed as the meanhanced expression of plasmid Luc in mice pretreated with plasmidGM-CSF
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