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Attenuation of Bunyamwera Orthobunyavirus Replication by Targeted Mutagenesis of Genomic Untranslated Regions and Creation of Viable Viruses with Minimal Genome Segments

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Figure

FIG 1 Schematic of the deletions introduced in the UTRs of the L segment(upper part) and M segment (lower part)
TABLE 1 Combinations of three deleted segments attempted in rescue experiments
FIG 4 Plaque phenotypes of mutant viruses at p0, p5, and p10 in BHK-21cells. BHK-21 cells were infected with wtBUNV or different minimal genomerecombinant BUNVs
TABLE 2 List of nucleotide and amino acid substitutions in the Lsequence of mutant virusesa

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